By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a consultant to new thoughts and techniques to deciding on and characterizing small molecules in early drug discovery. Biophysical tools are reasserting their software in drug discovery and during a mix of the increase of fragment-based drug discovery and an elevated concentrate on extra nuanced characterisation of small molecule binding, those tools are enjoying an expanding position in discovery campaigns.
This textual content emphasizes sensible issues for choosing and deploying center biophysical strategy, together with yet no longer restricted to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics lined include:
• layout issues in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing goals and screening reagents with HDX-MS
• Microscale thermophoresis equipment (MST)
• Screening with vulnerable Affinity Chromatography
• tips on how to investigate compound place of abode time
• 1D-NMR tools for hit identification
• Protein-based NMR tools for SAR development
• case experiences integrating a number of biophysical methods
This textual content is perfect for tutorial investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Additional resources for Applied Biophysics for Drug Discovery
Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler